Construction of Drug Network Based on Side Effects and Its Application for Drug Repositioning
نویسندگان
چکیده
منابع مشابه
Construction of Drug Network Based on Side Effects and Its Application for Drug Repositioning
Drugs with similar side-effect profiles may share similar therapeutic properties through related mechanisms of action. In this study, a drug-drug network was constructed based on the similarities between their clinical side effects. The indications of a drug may be inferred by the enriched FDA-approved functions of its neighbouring drugs in the network. We systematically screened new indication...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0087864